Thermo Fisher Scientific Phospho-SIRT1 (Thr530) Recombinant Rabbit Monoclonal Antibody (JJ206-6)
Phospho-SIRT1 (Thr530) 인산화 부위를 특이적으로 인식하는 recombinant rabbit monoclonal antibody. Western blot, IHC, ICC, Flow cytometry에 적합하며 높은 특이성과 재현성을 제공합니다. HEK293 발현 시스템에서 생산된 동물 유래 성분 무첨가 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ206-6 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Thr530 of Human SIRT1 (aa 501–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809713 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation to intracellular energetics and coordinates multiple cellular functions such as cell cycle control, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function via histone deacetylation and promotes methylation changes leading to transcriptional repression. It is essential for skeletal muscle differentiation and mediates inhibitory effects on myoblast differentiation under low nutrient conditions through AMPK and NAMPT pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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