Thermo Fisher Scientific WNT4 Polyclonal Antibody
WNT4 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 사용 가능. 다양한 종에 높은 반응성을 보이며, 4°C 단기 보관 및 -20°C 장기 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:10,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Item | Description |
|---|---|
| Published species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–306 of Human WNT4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2544797 |
Product Specific Information
- Recommended positive controls: 293T, HepG2, WNT4-transfected 293T lysate, V5-human Wnt4-transfected 293T
- Predicted reactivity: Mouse (100%), Rat (99%), Japanese Medaka (84%), Xenopus laevis (90%), Chicken (89%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The WNT gene family consists of structurally related genes encoding secreted signaling proteins involved in oncogenesis and developmental processes such as cell fate regulation and embryonic patterning.
WNT4 is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein with 98% amino acid identity to mouse and rat Wnt4.
WNT4 and nuclear receptors that antagonize testis-determining factors regulate female development and prevent testes formation.
WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue.
Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and SERKAL syndrome.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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