Thermo Fisher Scientific HDAC3 Polyclonal Antibody
HDAC3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, IP, ChIP 등 다양한 응용에 사용 가능. 고순도 Protein G 정제, 1.0 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함. 연구용으로만 사용.
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Thermo Fisher Scientific HDAC3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 |
| Immunocytochemistry (ICC/IF) | 1:10 |
| Immunoprecipitation (IP) | 1:10–1:500 |
| ChIP assay (ChIP) | 1:20–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 2–17 of human HDAC3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1074999 |
Product Specific Information
Suggested positive control: HeLa whole cell extract, antigen standard for HDAC3 (transient overexpression lysate).
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in transcription regulation through binding with the zinc-finger transcription factor YY1.
This protein can down-regulate p53 function and modulate cell growth and apoptosis. The HDAC3 gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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