Thermo Fisher Scientific NOD1 Polyclonal Antibody
NOD1 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 마우스 시료에 반응합니다. Western blot 및 IHC(P) 분석에 적합하며, 항원은 인간 NOD1의 930-949 아미노산 서열 기반 합성 펩타이드입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,500 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 930–949 of human NOD1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum with 50% glycerol |
| Contains | 0.025% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2151340 |
Product Specific Information
Suggested positive control: antigen standard for NOD1 (transient overexpression lysate), recombinant fusion protein.
Target Information
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, which plays a key role in innate immune defense. It contains:
- An N-terminal caspase recruitment domain (CARD)
- A centrally located nucleotide-binding domain (NBD)
- Ten tandem leucine-rich repeats (LRRs) at the C-terminus
The CARD domain participates in apoptotic signaling and activation of caspase-9 and NF-κB. LRRs mediate protein-protein interactions, and mutations in the NBD can affect oligomerization and LRR function. NOD1 acts as an intracellular pattern-recognition receptor (PRR) that triggers inflammation in response to bacteria containing diaminopimelic acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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