Thermo Fisher Scientific TLR2 Polyclonal Antibody

Thermo Fisher Scientific TLR2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Suggested positive control: bronchial epithelial cells (UBH16E), THP-1, or transfected human TLR2 cell lysate, antigen standard for TLR2 (transient overexpression lysate).

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family, playing a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins. It is highly conserved across species and expressed abundantly in peripheral blood leukocytes, mediating host response to Gram-positive bacteria and yeast.
TLR2 expression varies among cell types and is modulated by immune response modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-gamma, and TNF downregulate its expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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