Thermo Fisher Scientific TLR2 Polyclonal Antibody
TLR2 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 및 생쥐 시료에 반응. WB, IHC, ICC 등 다양한 응용 가능. 고순도의 Protein G 정제 및 1 mg/mL 농도. 병원체 인식 및 선천면역 연구에 적합.
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Thermo Fisher Scientific TLR2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–3 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | - |
| Flow Cytometry (Flow) | Assay-Dependent | - |
| Immunoprecipitation (IP) | Assay-Dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to residues 180–196, 353–370, and 473–489 of human TLR2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087895 |
Product Specific Information
Suggested positive control: bronchial epithelial cells (UBH16E), THP-1, or transfected human TLR2 cell lysate, antigen standard for TLR2 (transient overexpression lysate).
Target Information
TLR2 is a member of the Toll-like receptor (TLR) family, playing a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 forms heterodimers with TLR1 or TLR6 to recognize bacterial and mycoplasma lipoproteins. It is highly conserved across species and expressed abundantly in peripheral blood leukocytes, mediating host response to Gram-positive bacteria and yeast.
TLR2 expression varies among cell types and is modulated by immune response modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2, while IL-4, IFN-gamma, and TNF downregulate its expression in monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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