Thermo Fisher Scientific Phospho-ALOX5 (Ser523) Polyclonal Antibody
Phospho-ALOX5 (Ser523) 항체로 인산화된 5-Lipoxygenase를 특이적으로 검출. Western blot 및 ICC/IF에 적합. Rabbit polyclonal IgG 형식으로 1 mg/mL 농도. PBS/glycerol buffer에 보관하며 -20°C에서 안정적.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALOX5 (Accession P09917), corresponding to amino acid residues around phosphorylated Ser523. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818083 |
Product Specific Information
This antibody detects endogenous levels of 5-Lipoxygenase only when phosphorylated at Serine 523.
Target Information
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites involved in inflammatory responses such as asthma, arthritis, and psoriasis. The protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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