Thermo Fisher Scientific Phospho-GAB2 (Tyr452) Polyclonal Antibody
인간, 생쥐, 랫트에서 인산화된 GAB2 Tyr452를 특이적으로 검출하는 폴리클로날 항체. Western blot에 적합하며, 고순도 및 안정적인 액상 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- PA599146
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAB2 (Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Tyr452 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818079 |
Product Specific Information
Antibody detects endogenous levels of Gab2 only when phosphorylated at Tyrosine 452.
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domains and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, as well as T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high-affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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