Thermo Fisher Scientific HFE2 Monoclonal Antibody (08)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human Hemojuvelin/HFE2.

Target Information

HFE2 is involved in iron metabolism. It may be a component of the signaling pathway that activates hepcidin or acts as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in this gene are the cause of hemochromatosis type 2A (juvenile hemochromatosis, JH), an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically occurring before age 30.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.