Thermo Fisher Scientific HFE2 Monoclonal Antibody (08)
휴먼 HFE2 단백질을 인식하는 Mouse IgG1 단클론 항체로, ELISA에 최적화되어 있습니다. 보존제가 없는 액상 형태이며 Protein A로 정제되었습니다. 철 대사 관련 연구 및 HFE2 기능 분석에 적합합니다.
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Applications
- ELISA (ELISA)
Tested Dilution: 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 08 |
| Immunogen | Recombinant Human Hemojuvelin/HFE2 Protein (Met1–Ser399) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785212 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human Hemojuvelin/HFE2.
Target Information
HFE2 is involved in iron metabolism. It may be a component of the signaling pathway that activates hepcidin or acts as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.
Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Defects in this gene are the cause of hemochromatosis type 2A (juvenile hemochromatosis, JH), an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis, and cardiomyopathy, typically occurring before age 30.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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