Thermo Fisher Scientific Phospho-GAB2 (Ser159) Polyclonal Antibody
GAB2 단백질의 Ser159 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 파라핀 절편 면역조직화학에 적합. 인간, 생쥐, 랫트 반응성. 고순도 정제 및 -20°C 보관.
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Thermo Fisher Scientific Phospho-GAB2 (Ser159) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAB2 (Accession Q9UQC2), corresponding to amino acid residues around phosphorylated Ser159 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816714 |
Product Specific Information
Antibody detects endogenous levels of Gab2 only when phosphorylated at Ser159.
Target Information
This gene belongs to the GRB2-associated binding protein (GAB) family. These proteins contain a pleckstrin homology (PH) domain and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They function as adapters transmitting signals in response to cytokine and growth factor receptor activation, as well as T- and B-cell antigen receptor stimulation. The encoded protein is a key activator of phosphatidylinositol-3 kinase upon high-affinity IgE receptor activation. Two alternatively spliced transcripts encoding different isoforms have been identified.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-105241_GAB2_Q9UQC2-1_Rabbit_PDP.jpeg)
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