Thermo Fisher Scientific Phospho-RIP3 (Ser316) Polyclonal Antibody
RIPK3의 Ser316 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 인간 RIPK3 단백질 검출에 사용. 1 mg/mL 농도의 액상형 항체로, PBS 및 50% glycerol 버퍼에 보관.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RIPK3 (Accession Q9Y572), corresponding to amino acid residues around phosphorylated Ser316 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816719 |
Product Specific Information
Antibody detects endogenous levels of RIPK3 only when phosphorylated at Ser316.
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm and mitochondrion, capable of nucleocytoplasmic shuttling via nuclear localization and export signals. It is a component of the TNF receptor-I signaling complex, can induce apoptosis, weakly activate NF-kappaB, and interacts with caspase-8 and CFLAR to regulate necrosis and apoptosis pathways.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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