Thermo Fisher Scientific Phospho-TACC3 (Ser558) Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Phospho-TACC3 (Ser558) 특이적 Rabbit Polyclonal Antibody. Western blot에서 사용 가능하며, Ser558 인산화 상태의 TACC3를 선택적으로 검출. 1 mg/mL 농도의 액상 형태로 PBS/glycerol buffer에 보관. 연구용으로만 사용.
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- PA5105244
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TACC3 (Accession Q9Y6A5), corresponding to amino acid residues around phosphorylated Ser558 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816717 |
Product Specific Information
Antibody detects endogenous levels of TACC3 only when phosphorylated at Ser558.
Target Information
TACC1 is located on the 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1, whose expression is enhanced in most breast cancer tumors.
TACC family members—TACC1, TACC2, and TACC3—map closely to the corresponding FGFR1, FGFR2, and FGFR3 genes on chromosomes 4, 8, and 10.
Since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation.
TACC1 contains a conserved C-terminal region as in the Drosophila homolog D-TACC. D-TACC is necessary for normal spindle function, and mammalian TACC proteins appear to interact with centrosomes and microtubules similarly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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