Thermo Fisher Scientific Renal Cell Carcinoma/gp200 (Carbonic Anhydrase IX) Monoclonal Antibody (SPM487)
Renal Cell Carcinoma/gp200 (Carbonic Anhydrase IX) 단클론 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합합니다. Human 및 Horse 반응성이 있으며, Protein A/G 정제, PBS 저장, 보존제 무첨가. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Horse, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM487 |
| Immunogen | Microsomal fraction of human renal cortical tissue homogenate |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Carbonic anhydrase (CA) is an enzyme that catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues.
CA IX is one of the most hypoxia-inducible genes due to its stability and membrane localization. Carbonic anhydrases regulate pH in normal tissues by controlling hydrogen ion (H⁺) flux.
Blocking CA IX increases cell death under hypoxia, making it a reliable histochemical marker of hypoxia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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