Thermo Fisher Scientific Renal Cell Carcinoma/gp200 (Carbonic Anhydrase IX) Monoclonal Antibody (SPM487)
Renal Cell Carcinoma/gp200 (CA IX) 단일클론 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 사용 가능. Human 및 Horse 반응성. Protein A/G 정제, PBS 완충액에 보존. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Horse, Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM487 |
| Immunogen | Microsomal fraction of human renal cortical tissue homogenate |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Carbonic anhydrase (CA) is an enzyme that catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, and is abundant in mammalian tissues.
CA IX is one of the most inducible genes under hypoxia, regulated via HIF-1 alpha, and serves as a reliable histochemical marker of hypoxia due to its stability and membrane localization.
Carbonic anhydrases play a key role in regulating pH by controlling hydrogen ion flux, which impacts cell survival under hypoxic conditions. Inhibition of CA IX can increase cell death under hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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