Thermo Fisher Scientific CD20 Monoclonal Antibody (L26), eBioscience
CD20 단백질을 인식하는 L26 클론 단일클론 항체로, 인간 및 원숭이 시료에 반응합니다. IHC, WB, IP 등 다양한 응용에 사용 가능하며, Rituximab 등 치료용 항체의 결합에 영향을 받지 않습니다. 고순도 정제된 액상 형태로 연구용에 적합합니다.
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Thermo Fisher Scientific CD20 Monoclonal Antibody (L26), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | - |
| Immunohistochemistry (IHC) | - | 7 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL | 1 publication |
| Immunohistochemistry (Frozen) (IHC-F) | 5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | 3 publications |
| Immunoprecipitation (IP) | Assay-Dependent | - |
| Miscellaneous PubMed (Misc) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cynomolgus monkey, Human, Rhesus monkey |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | L26 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864840 |
Available Conjugated Formats
- Alexa Fluor 488
- Alexa Fluor 514
- Alexa Fluor Plus 647
- Alexa Fluor Plus 750
- eFluor 615
- eFluor 660
- Request custom conjugation available
Product Specific Information
The monoclonal antibody L26 recognizes human CD20, a transmembrane protein found on precursor and mature B lymphocytes. Expression is lost upon differentiation to plasma cells. CD20 levels are critical for evaluating malignant B lymphocytes including Non-Hodgkin’s Lymphoma, and various B-cell leukemias.
CD20 plays a role in B-cell differentiation and activation. The L26 antibody recognizes an epitope in the cytoplasmic domain, requiring tissue permeabilization for staining. Unlike antibodies targeting extracellular domains, L26 binding is not blocked by therapeutic antibodies such as Rituximab.
Applications Reported: IHC (frozen and paraffin-embedded tissue), WB, IP
Applications Tested: IHC of human FFPE tonsil with low pH antigen retrieval; ≤5 µg/mL recommended.
Antigen retrieval conditions affect staining quality and morphology. Optimized for IHC; not recommended for flow cytometry (use clone 2H7 for flow cytometry).
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and malignant B cells, some T cells, and follicular dendritic cells. It regulates calcium conductance, cell cycle progression, and B-cell proliferation. CD20 is associated with lipid rafts and participates in BCR signaling dynamics. Its stable membrane expression makes it a key therapeutic target for B-cell depletion in malignancies.
Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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