Thermo Fisher Scientific ID3 Monoclonal Antibody (OTI8B3), TrueMAB
ID3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC, Flow Cytometry에 사용 가능. HEK293T에서 생산된 full-length human ID3를 면역원으로 함. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B3 |
| Immunogen | Full length human recombinant protein of human ID3 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Members of the Id family of basic helix-loop-helix (bHLH) proteins include ID1, ID2, ID3, and ID4. These proteins are ubiquitously expressed and form heterodimers with class A and B HLH proteins. Due to the absence of the basic region, the heterodimers cannot bind DNA, thereby negatively regulating DNA binding of bHLH proteins.
ID-type proteins inhibit muscle-specific gene expression by blocking E12 and Myo D DNA binding. During muscle differentiation, ID protein levels decrease, enabling E12/E47 to activate myogenic differentiation. Expression of ID proteins is growth factor-dependent, and reduction of ID mRNA via antisense oligonucleotides delays cell cycle reentry after growth factor stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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