Thermo Fisher Scientific RNF144B Monoclonal Antibody (OTI1E1), TrueMAB
인간 RNF144B 단백질(aa 1-256)을 항원으로 제작된 Mouse IgG1 단클론 항체. Flow Cytometry에 1:100으로 사용 가능. 동결건조 형태로 제공되며, PBS + trehalose buffer에 저장. 연구용으로만 사용.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–256 of human RNF144B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RNF144B is an E3 ubiquitin-protein ligase that transfers ubiquitin from E2 conjugating enzymes (UBE2L3 and UBE2L6) to target substrates such as LCMT2, promoting their degradation.
It induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Overexpression may reduce the stability of BAX, a pro-apoptotic protein, leading to protection from cell death; however, RNF144B is not inherently anti-apoptotic.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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