Thermo Fisher Scientific Androgen Receptor (AR) Monoclonal Antibody (ABM335)
Western blot 및 IHC(P) 검증된 Androgen Receptor 단클론 항체. Human, Mouse, Rat, Chicken 반응성. 핵 내 위치의 AR 단백질 검출에 적합. 단백질 A 정제, 0.5 mg/mL 농도, 4°C 보관.
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- 500-6634
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM335 |
| Immunogen | A synthetic peptide sequence comprising amino acids 301–321 of human androgen receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Prostate tissue/cells
- Cellular location: Nuclear
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR acts as a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is crucial for development and function of male reproductive organs such as the prostate and epididymis, and also plays roles in nonreproductive tissues including muscle, hair follicles, and brain. AR is a phosphoprotein involved in MAP kinase regulation; inhibition of the MEK1/2 pathway affects AR phosphorylation. Dysregulation of AR signaling is associated with diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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