Thermo Fisher Scientific c-Abl Monoclonal Antibody (ABM328)
c-Abl 단백질의 SH2 도메인을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 마우스 반응성. 단백질 A로 정제된 액상 항체로 0.5 mg/mL 농도. 세포 내 위치 분석 및 c-Abl 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 0.1–1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM328 |
| Immunogen | Synthetic peptide corresponding to SH2 domain of c-Abl protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Placenta or HeLa cell
- Cellular location: Cytoplasmic, nuclear
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
The DNA-binding activity of ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation, forming the Philadelphia chromosome, which fuses c-Abl sequences from chromosome 9 with the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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