Thermo Fisher Scientific CD326 (EpCAM) Monoclonal Antibody (323/A3), APC
인간 EpCAM(CD326)을 인식하는 마우스 단클론 항체로, APC로 결합되어 유세포분석(Flow Cytometry)에 적합합니다. 상피계통 및 다양한 암세포 마커 연구에 유용하며, 4°C 어둠 속에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 10 µL/10^6 cells
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 323/A3 |
| Immunogen | Human breast cancer MCF-7 cells |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898627 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 647
- FITC
- PE
- PE-Cyanine7
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
This antibody recognizes an extracellular epitope of CD326 (EpCAM), a marker of epithelial lineages, that is over-expressed in many carcinomas.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial cells. It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is linked to enhanced epithelial proliferation and is a marker for tumors of epithelial lineage. It is expressed on the baso-lateral cell surface in most simple epithelia and many carcinoma types, and helps distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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