Thermo Fisher Scientific CD326 (EpCAM) Monoclonal Antibody (323/A3), APC

Applications

• Flow Cytometry (Flow): 10 µL/10^6 cells
• View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• FITC
• PE
• PE-Cyanine7
• PerCP-Cyanine5.5
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD326 (EpCAM), a marker of epithelial lineages, that is over-expressed in many carcinomas.

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial cells. It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is linked to enhanced epithelial proliferation and is a marker for tumors of epithelial lineage. It is expressed on the baso-lateral cell surface in most simple epithelia and many carcinoma types, and helps distinguish adenocarcinomas from pleural mesotheliomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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