Thermo Fisher Scientific CD326 (EpCAM) Monoclonal Antibody (323/A3), FITC

Applications and Tested Dilution

• Flow Cytometry (Flow): 4 µL / 1×10⁶ cells

Product Specifications

Available Formats

• Unconjugated (MA1-10196)
• Alexa Fluor 488 (MA5-38713)
• Alexa Fluor 647 (MA5-38714)
• APC (MA5-38715)
• PE (MA5-38717)
• PE-Cyanine7 (MA5-38718)
• PerCP-Cyanine5.5 (MA5-38719)
• Custom conjugation available upon request

Product Specific Information

This antibody recognizes an extracellular epitope of CD326 (EpCAM), a marker of epithelial lineages that is overexpressed in many carcinomas.

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a Ca²⁺-independent homotypic cell adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression is associated with enhanced epithelial proliferation and is a characteristic marker of epithelial-derived tumors.
Ep-CAM is expressed on the basolateral surface of most simple epithelia and many carcinoma types and can help distinguish adenocarcinomas from pleural mesotheliomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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