Thermo Fisher Scientific EpCAM (CD326) Monoclonal Antibody (323/A3), PE

Applications

• Flow Cytometry (Flow): 10 µL/10^6 cells

Product Specifications

Additional Formats

• Unconjugated (MA1-10196)
• Alexa Fluor 488 (MA5-38713)
• Alexa Fluor 647 (MA5-38714)
• APC (MA5-38715)
• FITC (MA5-38716)
• PE-Cyanine7 (MA5-38718)
• PerCP-Cyanine5.5 (MA5-38719)
• Custom conjugation available

Product Specific Information

This antibody recognizes an extracellular epitope of CD326 / EpCAM, a marker of epithelial lineages that is over-expressed in many carcinomas.

Target Information

Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism through induction of proto-oncogene c-myc and cell cycle regulators cyclin A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression of Ep-CAM is linked to enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for epithelial lineage tumors.
Ep-CAM is located on the basolateral surface of most simple epithelia and many carcinoma types and can distinguish adenocarcinomas from pleural mesotheliomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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