Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Recombinant Rabbit Monoclonal Antibody (F13A1, 3772R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA-fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.

Target Information

The F13A1 gene encodes the coagulation factor XIII A subunit, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer of 2 A and 2 B subunits. The A subunits possess catalytic activity, while the B subunits serve as carrier molecules. Platelet factor XIII consists only of A subunits identical to those in plasma. Upon thrombin cleavage and calcium presence, plasma factor XIII dissociates B subunits to form the active enzyme, factor XIIIa. This enzyme catalyzes crosslinking between fibrin molecules, stabilizing clots, and also crosslinks α2-plasmin inhibitor or fibronectin to fibrin.
Factor XIII deficiency is classified as:

• Type I: Lack of both A and B subunits
• Type II: Lack of A subunit only
  These defects cause bleeding tendency, poor wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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