Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (F13A1, 1683)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• For IHC (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, then cool at room temperature for 20 minutes.

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer consisting of two A subunits and two B subunits. The A subunits have catalytic activity, while the B subunits act as carrier molecules. Platelet factor XIII contains only two A subunits identical to those in plasma. Upon activation by thrombin and calcium ions, the plasma factor XIII dissociates its B subunits, forming the active enzyme factor XIIIa, which functions as a transglutaminase to stabilize fibrin clots by crosslinking fibrin molecules and other proteins such as α2-plasmin inhibitor or fibronectin.
Deficiency in factor XIII can lead to bleeding disorders, impaired wound healing, and recurrent miscarriage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.