Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (SPM180)
Factor XIIIa 단백질을 인식하는 Mouse monoclonal antibody(SPM180)로, Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 연구용 응용에 적합. Human 반응성, Protein A/G 정제, PBS buffer, 무보존제, -20°C 보관.
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- 2162MSM2XP1ABX
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Thermo Fisher Scientific Factor XIIIa (Coagulation Factor XIIIA Chain) Monoclonal Antibody (SPM180)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| ELISA | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM180 |
| Immunogen | Recombinant fragment of human Factor XIIIa protein (aa46–181) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits, identical to those of plasma origin. Upon activation by thrombin and calcium, plasma factor XIII dissociates its B subunits and yields the active enzyme, factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the clot. Factor XIII also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin. Deficiency in Factor XIII can lead to bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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