Thermo Fisher Scientific PKC epsilon Monoclonal Antibody (H.51.9)
PKC epsilon 단백질을 인식하는 Rabbit 모노클론 항체로, Western blot에 적합합니다. 인간, 마우스, 원숭이, 랫트에서 반응하며 다른 PKC 아이소폼과 교차반응하지 않습니다. 액상 형태로 고순도 정제되어 연구용으로 사용됩니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H.51.9 |
| Immunogen | Synthetic peptide corresponding to human PKCε |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 405 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985232 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other PKC isoforms.
Target Information
The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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