Thermo Fisher Scientific NUP98 Monoclonal Antibody (J.750.3)
NUP98 단백질을 인식하는 Rabbit monoclonal antibody (Clone J.750.3). Western blot, ICC/IF, IP에 적합하며, 인간, 마우스, 랫드 등 다양한 종에 반응. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:400–1:1600 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | J.750.3 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Pro671 of human NUP98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 18 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_11006366 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin (NUP98) is generated from a 186 kDa precursor protein through proteolytic cleavage, producing both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.
Rat studies indicate that the 98 kDa nucleoporin functions as one of several docking site nucleoporins for transport substrates. In humans, the NUP98 gene can fuse with multiple genes following chromosomal translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). It is located in the imprinted gene domain of 11p15.5, a critical tumor-suppressor region associated with several cancers and syndromes, including Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various solid tumors. Alternative splicing yields several transcript variants, not all of which have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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