Thermo Fisher Scientific NUP98 Monoclonal Antibody (H.933.7)
NUP98 단백질을 인식하는 Rabbit monoclonal antibody로, WB 및 IP에 사용 가능. Human, Mouse, Rat 등 다양한 종에 반응. 고순도 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용.
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Thermo Fisher Scientific NUP98 Monoclonal Antibody (H.933.7)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | H.933.7 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Leu518 of human NUP98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985601 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Signal-mediated nuclear import and export occur through the nuclear pore complex (NPC), composed of ~50 unique proteins known as nucleoporins. The 98 kDa nucleoporin (NUP98) is produced via proteolytic cleavage of a 186 kDa precursor, yielding both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.
Rat studies indicate that NUP98 functions as a docking site for transport substrates. The human NUP98 gene can fuse with other genes in chromosome translocations associated with acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).
This gene resides within the imprinted 11p15.5 tumor-suppressor region, linked to Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers (lung, ovarian, breast).
Alternative splicing produces several transcript variants, not all of which have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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