Thermo Fisher Scientific MESDC2 Monoclonal Antibody (S.539.9)
MESDC2 단백질을 표적으로 하는 Rabbit Monoclonal 항체. Western blot 및 Immunoprecipitation에 적합. 인간, 마우스, 랫드 등 다양한 종에 반응. Wnt 신호 경로 연구 및 LRP5/LRP6 단백질 발현 연구에 유용. 연구용 시약으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S.539.9 |
| Immunogen | Recombinant human MESDC2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10989028 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MESDC2 is a chaperone that assists in the folding of beta-propeller/EGF modules within the low-density lipoprotein receptor (LDLR) family. It modulates the Wnt pathway by chaperoning the coreceptors LRP5 and LRP6 to the plasma membrane. MESDC2 is essential for embryonic polarity, mesoderm induction, and neuromuscular junction formation by promoting cell-surface expression of LRP4. It may also regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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