Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), Alexa Fluor 700

Thermo Fisher Scientific CD41 Monoclonal Antibody (MEM-06), Alexa Fluor 700

Applications

• Flow Cytometry (Flow)

Tested Dilution: 4 µL / 1×10⁶ cells
Publications: - References

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• APC
• Biotin
• FITC
• PE
• PerCP
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains: GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa).
CD41 is mainly expressed on platelets and megakaryocytes.
Recommended dilution: 100 µL of whole blood or 1×10⁶ cells in suspension.

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa alpha and 23 kDa beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor.
It plays a key role in blood coagulation by mediating platelet aggregation and binding to von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury.
CD41 is primarily expressed in the megakaryocyte-platelet lineage and is among antigens expressed during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia and Platelet-type 16 bleeding disorder.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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