Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (4B4-1)
CD137(4-1BB) 단클론 항체로 활성화된 T 세포의 CD137 단백질을 특이적으로 인식합니다. Flow Cytometry, ELISA, IP, Functional Assay 등 다양한 연구용으로 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. For Research Use Only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1–4 µg/mL |
| ELISA (ELISA) | Assay-Dependent |
| Immunoprecipitation (IP) | Assay-Dependent |
| Functional Assay (Functional) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Chimpanzee, Cynomolgus monkey, Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B4-1 |
| Immunogen | Recombinant human CD137 ectodomain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745518 |
Product Specific Information
This antibody recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
Functional Application: Inhibition.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling maintains the survival of activated T cells and CD8+ memory T cells, promotes clonal expansion of T cells, and suppresses myelopoiesis and dendritic cell development. Triggered CD137 induces cytokine release regulating peripheral monocyte survival. Soluble forms of CD137 may provide a negative control mechanism for certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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