Thermo Fisher Scientific CD137 (4-1BB) Monoclonal Antibody (4B4-1)
CD137(4-1BB) 단백질을 인식하는 mouse IgG1 단클론 항체로, 활성화된 T세포에서 발현되는 TNFR 계열 단백질 검출에 적합. Flow cytometry, ELISA, IP 등 다양한 면역분석에 사용 가능. 4°C 보관, Protein A 정제, PBS buffer 포함.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–4 µg/mL
- Publications: [References not provided]
ELISA
- Tested Dilution: Assay-dependent
- Publications: [References not provided]
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Baboon, Chimpanzee, Cynomolgus monkey, Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B4-1 |
| Immunogen | Recombinant human CD137 ectodomain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745519 |
Product Specific Information
This antibody recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling maintains the survival of activated T cells and CD8+ memory T cells, promotes clonal expansion, and regulates cytokine release affecting monocyte survival. Soluble CD137 may act as a negative regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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