Thermo Fisher Scientific HEXB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 0.5–1 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a tetramer of two β-A and two β-B chains localized in lysosomes. Mutations in the HEXB gene cause Sandhoff disease (GM2-gangliosidosis type II), an autosomal recessive disorder leading to accumulation of GM2 ganglioside and progressive destruction of the central nervous system. This condition is more severe than Tay-Sachs disease, which results from mutations in the HEXA gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.