Thermo Fisher Scientific HIF3A Polyclonal Antibody
인간 및 랫트에서 반응하는 HIF3A 단클론 항체로, Western blot에 적합합니다. C-말단 합성 펩타이드로 면역화된 rabbit IgG 폴리클론 항체입니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human HIF3 (497–514aa DDDFQLNASEQLPRAYHR) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746478 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors (HIFs), including HIF-1α, HIF-1β (Arnt 1), EPAS-1 (HIF-2α), and HIF-3α, play key roles in inducing glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis. These factors belong to the Per-Arnt-Sim (PAS) domain transcription factor family. Under hypoxic conditions, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to create the HIF-1 complex, which binds to the hypoxia responsive element (HRE) of target genes to activate transcription.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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