Thermo Fisher Scientific WNK1 Polyclonal Antibody
Thermo Fisher Scientific의 WNK1 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, WNK1 단백질 연구 및 전해질 항상성 관련 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human WNK1 (1154–1195aa DNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSED) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage conditions | −20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747343 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II.
WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It acts as both activator and inhibitor of sodium-coupled and potassium-coupled chloride cotransporters, respectively.
Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis (distal nephron). Mutations in the WNK gene result in pseudohypoaldosteronism and neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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