Thermo Fisher Scientific WRN Polyclonal Antibody
WRN 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 및 랫트 시료에 반응합니다. Western blot에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. DNA 복구 및 헬리케이스 연구용으로 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived human WRN recombinant protein (Position: Q122–N240) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747346 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
The WRN gene encodes a member of the RecQ and DEAH subfamilies of DNA/RNA helicases. These helicases are involved in transcription, replication, recombination, and repair. The WRN protein contains a nuclear localization signal in the C-terminus and localizes predominantly to the nucleolus. It exhibits intrinsic 3′ to 5′ DNA helicase and exonuclease activities. Interaction with Ku70/80 suggests involvement in double-strand DNA break repair. Mutations in this gene cause Werner syndrome, a disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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