Thermo Fisher Scientific TH Monoclonal Antibody (OTI1A10), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine.
TH activity is regulated through interaction with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains.
TH catalyzes the conversion of L-tyrosine to L-dopa and plays a central role in adrenergic neuron physiology.
Alterations in TH expression or activity are associated with neurological and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.