Thermo Fisher Scientific TH Monoclonal Antibody (OTI1A12), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by TH interaction with the cofactor tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.

In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified. These share identical catalytic domains but differ in their N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.

Alterations in TH activity are associated with several neuropathogenic and cardiovascular diseases, including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.