Thermo Fisher Scientific ILP-2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

• PA1-4276 detects the ILP-2 protein in human samples.
• PA1-4276 has been successfully used in Western blot procedures.
• PA1-4276 immunogen corresponds to amino acid residues 71–84 of the human ILP-2 protein.

Target Information

Apoptosis, or programmed cell death, is related to many diseases such as cancer. Apoptosis is triggered by various stimuli including members of the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibit specific proteases.
A novel member in the IAP protein family was identified and designated ILP-2 (IAP-like protein-2). ILP-2 has high homology to ILP-1 but is encoded by a distinct gene expressed solely in testis of normal human tissues. Unlike ILP-1, ILP-2 has no inhibitory effect on Fas and TNF-induced apoptosis but potently inhibits apoptosis induced by Bax overexpression or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with processed caspase-9, suggesting that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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