Thermo Fisher Scientific MAP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide: E(337) E E A L L Q A I L E G N F T(351) of the human MAP-1 protein if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MAP1,uniProtId:Q96BY2-1,ncbiNodeId:9606,antigenRange:337-351,antigenLength:351,antigenImageFileName:PA1-4271_MAP1_Q96BY2-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4271_MAP1_Q96BY2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2266563

Product Specific Information

PA1-4271 detects the MAP-1 (Modulator of Apoptosis) protein in human samples.

PA1-4271 has been successfully used in Western blot procedures. This antibody detects a ~36 kDa protein representing human MAP-1 in 293T cells.

PA1-4271 immunizing peptide corresponds to amino acid residues 337-351 of the human MAP-1 protein.

Target Information

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.