Thermo Fisher Scientific APP Monoclonal Antibody (OTI7A10), TrueMAB
APP 단백질을 인식하는 Mouse Monoclonal Antibody로 Western blot 및 IHC(P) 검증됨. 인간 시료에 반응하며, Lyophilized 형태로 제공. PBS buffer와 trehalose 포함, -20°C 보관. Alzheimer’s disease 연구에 유용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A10 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
It is crucial for neurite growth, neuronal adhesion, and axonogenesis.
APP is a 100–140 kDa transmembrane glycoprotein with multiple isoforms from alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques in Alzheimer’s disease.
Abnormal APP processing is also associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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