Thermo Fisher Scientific TMEM173 Monoclonal Antibody (OTI1A3), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:200–1:1,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

STING (TMEM173) is a 379-amino-acid signaling protein crucial for innate immune signaling. It activates NF-κB and IRF3 transcription pathways to induce type I interferons (IFN-α, IFN-β), establishing an antiviral state.
STING may also function as a translocon influencing interferon induction and mediates apoptotic signaling via MHC-II association. It is involved in detecting intracellular viral RNA and B-form DNA, and mediates death signaling through ERK pathway activation.
Localization includes endoplasmic reticulum membrane, cell membrane, and mitochondrion outer membrane, and it is ubiquitously expressed in most tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.