Thermo Fisher Scientific APP Monoclonal Antibody (OTI4C9), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
APP plays a key role in neurite growth, neuronal adhesion, and axonogenesis.
It is a 100–140 kDa transmembrane glycoprotein existing in several isoforms due to alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, a major component of senile plaques — characteristic of Alzheimer’s disease.
Abnormal APP processing is also associated with Down’s syndrome, familial Alzheimer’s disease, and cerebral hemorrhage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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