Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) Monoclonal Antibody (ENO2/1462)
Neuron Specific Enolase(gamma) 단클론 항체로 신경 및 신경내분비 세포 마커로 사용. 사람 NSE 감지에 적합하며 IHC 및 Peptide Array에 적용 가능. 고순도 Protein A/G 정제, 보존제 무첨가 PBS 용액 형태로 제공.
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Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) Monoclonal Antibody (ENO2/1462)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.1–0.2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ENO2/1462 |
| Immunogen | Synthetic peptide of human NSE gamma (aa 416–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. NSE is stable in biological fluids and diffuses easily into extracellular medium and cerebrospinal fluid (CSF) when neuronal membranes are damaged.
NSE is one of three mammalian enolases:
- ENO1 (alpha): expressed in most tissues
- ENO2 (gamma): expressed primarily in neurons and neuroendocrine cells
- ENO3 (beta): expressed only in muscle
Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms. NSE antibodies are useful for identifying neuronal cell bodies, developing neuronal lineages, and neuroendocrine cells. Release of NSE from damaged neurons into CSF and blood serves as a biomarker of neuronal injury.
Clinically, NSE is used as a sensitive marker for neuronal damage in conditions such as:
- Stroke
- Hypoxic brain damage
- Status epilepticus
- Creutzfeldt-Jakob disease
- Herpetic encephalitis
- Pediatric neuroblastoma
- Small cell lung cancer
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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