Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) Monoclonal Antibody (NSE-P2)

Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) Monoclonal Antibody (NSE-P2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA-fixed): Incubate antibody for 30 min at room temperature (RT).
• For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, then cool at RT for 20 min.

Target Information

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme involved in glycolysis and gluconeogenesis, catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate.
NSE exhibits high stability in biological fluids and diffuses easily into extracellular media and cerebrospinal fluid (CSF) upon neuronal injury.

• The gamma-subunit is primarily expressed in neurons and neuroendocrine cells.
• Co-expression with chromogranin A is common in neuroendocrine neoplasms.
• Antibodies to NSE are useful for identifying neuronal cell bodies, developing neuronal lineage, and neuroendocrine cells.
• NSE release serves as a biomarker for neuronal injury and is clinically used to assess damage in conditions such as stroke, hypoxic brain injury, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis.
• Elevated plasma NSE levels are associated with neuroblastoma and small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음 또는 별도 제공 시 하단에 배치)