Thermo Fisher Scientific Calmodulin Recombinant Rabbit Monoclonal Antibody (SJ16-09)
Calmodulin 단백질을 인식하는 재조합 토끼 단일클론 항체로, 높은 특이성과 민감도를 제공. Western blot, IHC, ICC/IF 등 다양한 응용 가능. HEK293 세포에서 발현된 IgG 형 항체로 일관된 로트 간 품질 유지. 연구용으로만 사용.
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Thermo Fisher Scientific Calmodulin Recombinant Rabbit Monoclonal Antibody (SJ16-09)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunohistochemistry (Frozen) (IHC (F)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SJ16-09 |
| Immunogen | Synthetic peptide within Human Calmodulin (aa 100–149) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809368 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
Calmodulin mediates control of numerous enzymes, ion channels, aquaporins, and other proteins via Ca²⁺ regulation. The calmodulin–Ca²⁺ complex stimulates various protein kinases and phosphatases. Together with CCP110 and centrin, it participates in a genetic pathway regulating the centrosome cycle and cytokinesis.
Calmodulin is a small, highly conserved calcium-binding protein (17 kDa) found in all eukaryotic cells. It binds up to four calcium ions and undergoes conformational changes that enhance affinity for target proteins. It functions directly by interacting with target enzymes and indirectly via specific kinases.
Biological roles include:
- Regulation of metabolism and cell motility
- Exocytosis and cytoskeletal assembly
- Modulation of intracellular cAMP and calcium levels
- Participation in growth, cell cycle, and neurotransmitter synthesis
Calmodulin consists of 149 amino acids and contains four calcium-binding domains. It is the archetype of calcium-modulated proteins found in the cytosol or on cytosolic-facing membranes with high calcium affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: MA5-32074_Calmodulin_P0DP23-1_Rabbit.svg, MA5-32074_Calmodulin_P0DP23-1_Rabbit_PDP.jpeg)
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