Thermo Fisher Scientific LDLR Recombinant Rabbit Monoclonal Antibody (SJ0197)
Thermo Fisher Scientific의 LDLR Recombinant Rabbit Monoclonal Antibody (SJ0197)은 인간 LDL 수용체를 타겟으로 하는 고특이성 항체입니다. Western blot, IHC, ICC, Flow cytometry에 적합하며, 일관된 로트 간 재현성과 높은 감도를 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
| Flow Cytometry (Flow) | 1:50–1:100 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SJ0197 |
| Immunogen | Synthetic peptide within Human LDL Receptor (aa 811–860) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809369 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulation
- Broader immunoreactivity due to rabbit immune repertoire
For flow cytometry, cells should be fixed and permeabilized before staining.
Target Information
The Low Density Lipoprotein Receptor (LDLR) gene family encodes cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds to the cell membrane and is internalized into lysosomes, where it is degraded, releasing cholesterol that suppresses HMG CoA reductase activity—the rate-limiting enzyme in cholesterol synthesis.
Mutations in the LDLR gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDLR, along with SCARB1, CLDN1, and CD81, has also been reported as an entry factor for the Hepatitis C virus. At least three isoforms of LDLR are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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