Thermo Fisher Scientific NFATC1 Monoclonal Antibody (7A6)
NFATC1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 7A6). Western blot, IHC, ICC, IP, ChIP 등 다양한 응용에 사용 가능. Human, Mouse, Rat 등 반응. 비결합형 액상 항체로 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | 44 |
| Immunohistochemistry (IHC) | – | 7 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | 1 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | Assay-dependent | – |
| Immunocytochemistry (ICC/IF) | 1:250 | 12 |
| Flow Cytometry (Flow) | – | 1 |
| Immunoprecipitation (IP) | Assay-dependent | 3 |
| ChIP assay (ChIP) | Assay-dependent | 8 |
| Gel Shift (GS) | Assay-dependent | 12 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Hamster, Human, Mouse, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7A6 |
| Immunogen | Bacterially expressed GST fusion protein containing NFATC1 residues 1–654 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites, PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2236037 |
Product Specific Information
- MA3-024 detects NFATc1 (NFAT2) from transfected human, rat, mouse, and monkey cells.
- Does not cross-react with NFATc2 (NFAT1).
- Validated for Western blot, immunoprecipitation, ChIP, immunofluorescence, and gel shift assays.
- Detects an ~105 kDa band corresponding to transfected NFAT2 in COS cell lysate.
- Previously part of Thermo Scientific Cellomics High Content Screening Kit; now available as a standalone antibody optimized for high-content cell-based assays.
- Recommended for researchers performing cellular immunofluorescence (IF) applications. Further optimization may be required depending on assay conditions.
Target Information
NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic 1) is a component of the NFAT DNA-binding transcription complex, which regulates inducible gene transcription during immune responses.
This complex includes a cytosolic component that translocates to the nucleus upon TCR stimulation and an inducible nuclear component.
NFATC1 serves as a major molecular target for immunosuppressive drugs such as cyclosporin A.
Five transcript variants encoding distinct isoforms have been identified, potentially regulating different cytokine gene expressions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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