Thermo Fisher Scientific Calnexin Monoclonal Antibody (AF18), Alexa Fluor 488

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1–10 µg/mL
• View 4 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 555
• Alexa Fluor 647
• Request custom conjugation

Product Specific Information

MA3-027-A488 detects calnexin from human and mouse tissues.
The antigen used is Focus human hepatoma cell lysate.

Target Information

Calnexin, also known as IP90, p88, and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER).
It acts as a molecular chaperone involved in proper folding and assembly of polypeptides.
Calnexin associates with MHC class I heavy chains, partial complexes of T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes.
It retains incompletely folded proteins in the ER.
Soluble ER resident proteins contain the KDEL sequence for retention, while integral membrane proteins like calnexin rely on positively charged cytosolic residues for ER localization.
Calnexin consists of:

• ER luminal domain: 461 amino acids
• Transmembrane segment: 22 amino acids
• Cytoplasmic tail: 89 amino acids

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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