Thermo Fisher Scientific HSP60 Monoclonal Antibody (A57-B9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA3-023 detects heat shock protein 60 kDa (HSP60) from bacteria.
This antibody detects all three species of Chlamydia HSP60 with minimal cross-reactivity with Borrelia burgdorferi HSP60.
It does not react with E. coli GroEL.

MA3-023 has been successfully used in Western blot and immunoprecipitation procedures.
By Western blot, this antibody detects a single ~60 kDa band representing HSP60 from C. trachomatis lysate.

The immunogen is recombinant Chlamydia trachomatis HSP60.
Epitope mapping studies suggest that this antibody binds to a linear sequence of Chlamydia HSP60 amino acids 517–522.

Target Information

This gene encodes a member of the chaperonin family.
The encoded mitochondrial protein may function as a signaling molecule in the innate immune system and is essential for folding and assembly of newly imported mitochondrial proteins.
The gene is adjacent to a related family member, and the intergenic region acts as a bidirectional promoter.
Several pseudogenes are associated with this gene.
Two transcript variants encoding the same protein have been identified.
Mutations in this gene cause autosomal recessive spastic paraplegia 13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.