Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7438)
STING1/TMEM173 단백질을 인식하는 Mouse monoclonal 항체로, WB 및 IHC 분석에 적합합니다. 인간 시료 반응성이 있으며, PBS buffer에 보존된 액상 형태입니다. 단백질 A/G 정제, 항바이러스 및 면역 신호 연구용으로 최적화된 연구용 시약입니다.
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Thermo Fisher Scientific STING1/TMEM173 Monoclonal Antibody (STING1/7438)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STING1/7438 |
| Immunogen | Recombinant fragment (around aa190–290) of human TMEM173 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Target Information
STING is a 379 amino acid signaling protein that plays a key role in innate immune signaling. It activates NF-κB and IRF3 pathways to induce type I interferon (IFN-α and IFN-β) expression, establishing an antiviral state. STING may function as a translocon influencing interferon induction and apoptotic signaling through its association with MHC-II. It mediates detection of intracellular viral RNA and B-form DNA, and activates the ERK pathway for death signaling. STING is localized in the endoplasmic reticulum membrane, cell membrane, and mitochondrial outer membrane, and is ubiquitously expressed in most tissues.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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